Bio Complete 3 review

Bio Complete 3 Review: A “cure” for leaky gut?

Bio Complete 3


Short-term effects


Long-term effects







  • Tributyrin has never been shown to fix gut lining in humans, only in rats who were given a high ethanol diet!
  • 200mg of guar gum is NOT going to promote a healthy gut microbiome - pathetic dose
  • The best prebiotics contain several grams of prebiotic fiber
  • Only uses ONE probiotic bacteria - HIGHLY UNUSUAL!


Bio Complete 3 is yet another rip off gut health supplement from Gundry MD. This supplement is just some B. coagulans, a pathe5tically small dose of prebiotic fiber, and a triglyceride. This is not going to do anything amazing for your gut. Then there’s the fact that “leaky gut” is a made up illness anyway; as far s I can tell, it doesn’t exist! At the end of the day, if you need to fix a microbiome imbalance, use a full spctrum probiotic. If you want to optimize gut health over the long term, use a high quality prebiotic.

What is Gundry MD Bio Complete 3?

Bio Complete 3 is another gut health supplement from Gundry MD. Dr. Gundry has managed to create one of the most popular supplement brands in the US right now, seemingly out of nowhere. His range of supplements covers everything from digestive health to fat loss, and they are all premised on his thus-far unproven theory of “leaky gut syndrome”.

Bio Complete 3 review

According to the official Gundry MD website, Bio Complete 3 is an “all-in-one prebiotic, probiotic, and postbiotic formula” which can help you:

  1. Lose weight faster
  2. Lose “stubborn” body
  3. Reduce fatigue and increase energy
  4. Completely eradicate digestive issues
  5. Reduce cravings for unhealthy foods

Those are some pretty impressive claims for a humble gut health supplement. Of course, prebiotics and probiotics can promote fat loss and improve energy levels through improved digestive health.

So the question is, does Bio Complete 3 really work? Is it the best supplement for you and your gut? Is it safe? Read our detailed Bio Complete 3 review now and find out!

How is Bio Complete 3 supposed to work?

Gundry MD describes Bio Complete 3 as an all-in-one gut supplement. The “complete 3” part of the name refers to the fact that this supplement is supposed to be a prebiotic, a probiotic, and a post-biotic.

You’re forgiven if you’ve never heard of “post-biotic” before; neither have we!

So how is this gut health supplement supposed to work?

Prebiotics are water soluble fibers which feed your gut bacteria. Good prebiotics will selectively feed your health-promoting gut bacteria, helping them out-compete and dominate less healthful, or downright harmful bacteria species in the gut.

Probiotics are exogenous bacteria strains which are used to re-balance the gut microbiome. Probiotic supplements typically provide large quantities of the bacteria species which dominate a healthy, balanced gut. They may also deliver bacteria species which compete with harmful bacteria for the same food sources, thereby diminishing their ability to divide and grow.

How Bio Complete 3 works

Post-biotics is not a widely-used concept. In the case of Gundry MD Bio Complete 3, post-biotic means alleviating symptoms of “leaky gut syndrome” and strengthening the gut lining.

Gundry has a theory that lots of foods cause the gut to become more permeable, which he believes causes everything from heart disease to diabetes. Bio Complete 3 supposedly fixes the gut microbiome and then helps prevent this supposedly debilitating condition (which is yet to be shown to exist).

So that’s how Bio Complete 3 is supposed to work. But does it really do these things? Let’s take a look at the ingredients and find out!

Bio Complete 3 Ingredients

Here is the Bio Complete 3 ingredients list which you can see on the bottle:

Bio Complete 3 ingredients list

In case that image doesn’t load, here is a list of Bio Complete 3’s ingredients along with doses:

  • Tributyrin (as CoreBiome) – 1000mg
  • Sunfiber – 200mg
  • Bacillus coagulans (Pro DURA) – 16mg/2 billion CFU

Unsurprisingly, Bio Complete 3 has a three-part formula split into prebiotic, probiotic, and “postbiotic” components. Let’s look at these ingredients in a little more detail.

Tributyrin – 1000mg

Burtyate is a short-chain fatty acid; it is formed in the gut during the fermentation of undigested polysaccharides. Butyrate is known to have many important biological effects, including anti-inflammatory and immuno-protective effects.

Tributyrin is a triglyceride; it is used in the manufacturing of margarine. Thus far, it has only been studied in the context of chronic-binge ethanol exposure in mice. In other words, tributyrin has been shown to reduce oxidative stress and inflammation in the mouse colon during acute or chronic-binge ethanol exposure.

The average person does not experience chronic-binge ethanol exposure on a regular basis. The average person does not have the same colon as a mouse.

The inclusion of tributyrin in Bio Complete 3 is extremely concerning given that it has not been properly studied in humans and that it is thought to be cytotoxic in large doses. The science just doesn’t support the use of this Bio Complete 3 ingredient!

Sunfiber – 200mg

It is hard to find out exactly what Sunfiber is; the manufacturer’s website just tells you that it is an amazing fiber obtained from guar. There are no real details available on the website telling us how Sunfiber is made, what it contains, and so on.

Other sources claim that Sunfiber is partially hydrolyzed guar gum (PHGG). This would make sense; PHGG is an effective prebiotic which has been shown to stimulate the growth of probiotic bacteria and native gut microflora (source).

However, Bio Complete 3 gives us just 200mg of Sunfiber. That is a pathetically small dose if it turns out to be partially hydrolyzed guar gum. For some context, the studies showing the biggest improvements in digestive health from PHGG supplementation used about 6g of the stuff per day (source).

Bio Complete 3 doesn’t give us anywhere near enough Sunfiber to make a difference to your digestive health. Gundry MD is leveraging an effective ingredient’s name while keeping costs to a minimum!

Sunfiber prebiotic

Bacillus Coagulans – 2 Billion CFU

If you are going to use just one probiotic, then Bacillus Coagulans is not a bad option. This probiotic bacteria is commonly prescribed for combating viral diarrhea and diarrhea caused by antibiotics. So if you have persistent diarrhea and you suspect it is caused by harmful bacteria overgrowth, Bacillus Coagulans might be a good solution to try (under medical supervision of course).

However, this ingredient is not making us overly-enthusiastic about Bio Complete 3. Most high-quality, professionally-designed probiotics provide a cocktail of probiotic bacteria – in large quantities – which together redress imbalances in the gut microbiome.

There is no way for you to accurately judge the cause of your digestive issues without proper tests, so taking one single probiotic bacterium is a blind stab in the dark. This is why good probiotics provide a diverse array of bacteria which roughly resembles a healthy gut microbiome.

Bio Complete 3 has gone with just one probiotic bacterium, presumably to stick to the idea of being a three-pronged solution. But it has left it a weak, potentially harmful gut supplement capable of making imbalances worse.

Our thoughts on the Bio Complete 3 formula

If you’ve read our analysis of the Bio Complete 3 ingredients above, then you already know that we are far from impressed with this “all-in-one” gut supplement.

The number of ingredients in Bio Complete 3 is not the problem; the best prebiotics on the market now contain a similar number of ingredients. The primary problem with Bio Complete 3 is the ingredients chosen by Gundry MD.

We do not think any of the ingredients in Gundry MD Bio Complete 3 are going to make a significant, positive difference to your digestive health (and by extension, your body weight, metabolism, or energy levels).

Tributyrin is a triglyceride used in the manufacture of margerine; it has never been shown to have any positive effect on the gut lining of humans. The only studies showing that tributyrin has a positive effect on gut lining have been done on mice exposed to chronic-binge ethanol exposure.

Sunfiber is (as far as we know) a form of guar gum. It has been shown to improve digestion in numerous clinical trials, and it seems to be a great prebiotic for selectively feeding native, healthful gut microflora. However, studies showing it having a meaningful positive effect have given participants over 5g of the stuff per day! Bio Complete 3 gives us just 200mg, which is a pathetic dose.

The inclusion of just one probiotic bacteria in Bio COmplete 3 – a supplement which claims to be an “all-in-one” gut health stack – is almost laughable. Every good probiotic provides a comprehensive cocktail of bacteria to help rebalance the gut.

Going “all-in” on one bacterium is a risky approach to gut microbiome optimization; you risk making an imbalance even worse!

So all things considered, Bio Complete 3 is a poor choice of supplement if your goal is better gut health and improved digestion.

Gundry MD has tried to make this supplement a prebiotic, probiotic, and postbiotic. In the end, Bio Complete 3 is none of these things!

Bio Complete 3 Side Effects

Is Bio Complete 3 dangerous? Will it cause side effects?

The answer, unfortunately, is “probably yes” to both of these questions.

Tributyrin is known to be cytotoxic in large doses. It has not been properly tested for its suitability as a human dietary supplement. We certainly would not feel comfortable taking 1000mg of the stuff on a daily basis for a long period of time.

We’re also concerned that Bio Complete 3 describes itself as a “daily supplement” when probiotic bacteria should not be taken every day for prolonged periods of time.

Bio Complete 3 side effects

Consuming probiotic bacteria every day for extended periods of time will cause side effects, including:

  • Stomach cramps
  • Nausea
  • Constipation
  • Gas
  • Bloating
  • Diarrhea
  • Indigestion
  • Loss of appetite
  • Nutrient deficiency

The fact that Bio Complete 3 is highly unlikely to deliver substantial benefits means that any side effect risks are completely out-sized relative to potential gains.

The side effect risks of Bio Complete 3 are significant, especially when compared to high-quality probiotics and prebiotics.

This is not medical advice. We are not doctors. You must do your own research before using any supplements, including this one. If you have any pre-existing conditions at all, talk to a qualified medical doctor before using a gut supplement. If you have any concerns about Bio Complete 3’s ingredients, contact Gundry MD directly.

Bio Complete 3 Review Conclusion: Should you buy it?

Is Bio Complete 3 a good option for people looking to enhance their gut microbiome and promote optimal health?

No, not at all!

We think Gundry MD Bio Complete 3 is a complete waste of money. It is incapable of actually delivering on the promises made by the manufacturer; the ingredients are just not going to make a meaningful, positive impact on your gut microbiome.

If anything, we think Bio Complete 3 is likely to cause side effects if used on a daily basis, all without any notable improvements in digestive health.

If you want to learn why we have such an issue with this stack, please read our full review of Bio Complete 3’s formula. We explain in detail why the ingredients are completely useless when it comes to recitfying digestive issues.

If you want some help optimizing your gut microbiome for good overall health, dont’ waste your money on Gundry’s gimmicky supplements.

Instead, opt for a high-quality prebiotic which will selectively feed your native, health-promoting gut bacteria.

See our #1 recommended supplement for total gut health:

Performance Lab Prebiotic

Performance Lab Prebiotic gut health supplement

This is easily the best supplement on the market right now for optimizing your gut health over the long term. By selectively feeding your healthy gut bacteria with specially grown inulin-FOS prebiotic fiber, Performance Lab Prebiotic helps rebelance your gut microbiome and spur the growth of healthy bacteria species every signle day.

Visit the website ot learn more:

4 comments / Add your comment below

  1. Thank you very much for the review I was about to order bio complete 3 reading about it I’ve changed my mind I’m now looking for the best something that is better than Dr, Gunty methods

    1. Thanks for commenting Dorcus. Glad I could help. Bio Complete 3 is a classic Gundry supplement; cheap rubbish built on the idea of purely fictitious illnesses. Let me and other readers know if you find something better!

  2. After viewing Dr. Gundry‘s “sales pitch“ I was sold and was considering making the purchase. After reading what you all have presented here I am so glad that I found your website. Thank you so much for your objective and professional approach to the issues that drove me in search of a solution. The money I would’ve spent on bio complete three would’ve been a waste and potentially made my situation(s) worse.

  3. Why do you say “leaky guy” is fictitious? I believe in it being that I probably have all the symptoms of it. I do have SIBO and IBD, leaky gut only makes sense.

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