Nucific Bio X4 review

Nucific Bio X4 Review: A “weight-loss probiotic”? Nope!


Short-term effects


Long-term effects







  • Does provide a good range of probiotic bacteria
  • High-EGCG green tea extract will promote weight loss


  • Ridiculously over-priced for what you get
  • Probiotic bacteria species are fairly standard
  • Digestive enzymes are largely detroyed in stomach - POINTLESS INGREDIENTS
  • Slimaluma has never been properly tested in humans


Bio X4 is one of the most widely-used probiotic supplements on the market right now. Reviews typically rate it ver highly. However, I suspect this is because of bloggers being given incentives to review it positively; objectively speaking, there is nothing special about Nucific Bio X4 at all. It provides some basic probiotic bacteria and a couple of ingredients that are unlikely to really make any difference to your weight loss. Caralluma fimbriata is totally unproven; there’s no evidence that it controls appetite. Green tea extrac does very little. A good prebiotic will do more to help with weigth loss than Bio X4, especially with a few weeks of probiotic use thrown in.

What is Bio X4?

Nucific Bio X4 has got to be one of the most talked-about probiotics in the world. It is one of the few probiotics on sale today which claims to offer far more than just a healthier gut microbiome.

According to the Nucific Bio X4 bottle, this probiotic can:

  1. Manage cravings
  2. Promote weight management
  3. Boost metabolism
  4. Support smoother digestion

Bio X4 is sold primarily as a weight-loss supplement rather than as a probiotic or gut health supplement. A good probiotic can indeed help with weight management, appetite control, and digestion (all of which are interrelated).

Nucific Bio X4 review

The question is, does Bio X4 really work? Can it help with weight management? Is it safe? Is Bio X4 the best gut health supplement on offer right now? Read our full Bio X4 review below and find out.

How do probiotics work?

Before we discuss the particulars of Nucific Bio X4, it’s worth explaining how probiotics are supposed to work.

Probiotics are essentially just bacteria species which are known to affect gut microbiome in a positive way. They might be bacteria found naturally in high concentrations in a healthy human gut, or they might be known to out-compete harmful bacteria species in the gut, depriving them of the food they need to thrive.

In either case, the logic is that probiotics will help re-balance your gut microbiome in favor of healthy gut bacteria.

Most people could benefit from re-balancing their gut microbiome. The average person’s lifestyle today is not conducive to healthy gut bacteria growth: diets low in fiber and high in saturated fat, alcohol abuse, and high-stress working lives all suppress healthy gut bacteria.

So probiotics are designed to turn the tide, restoring a gut microbiome that is full of health-promoting bacteria and low in harmful species.

Bio X4 Benefits: What does this probiotic claim to do?

What are the supposed benefits of Bio X4?

According to Nucific, and Dr. Amy Lee (Bio X4’s creator), Bio X4 is a “4-in-1 supplement” providing a solution to four specific problems related to weight loss and weight management: appetite, cravings, digestion, and metabolism.

According to Dr. Amy Lee of Nucific, Bio X4 is an effective supplement for speeding up weight loss. Specifically, Dr. Amy Lee claims that Bio X4 is capable of reducing hunger, eliminating “bad” food cravings, helping with the regulation of blood sugar, and directly helping reduce waist circumference.

Of course, as a “potent probiotic”, Bio X4 also supposedly promotes digestive health, rebalances the gut microbiome, supports good immune system function, and helps alleviate some symptoms of irritable bowel syndrome. Of course, probiotics cannot reverse or cure any serious health condition. But good probiotics can support good digestive health.

Nucific Bio X4 Ingredients

Here is the Bio X4 ingredients list as you see it on the bottle:

Bio X4 ingredients list

In case that image fails to load, here is a list of the Bio X4 ingredients with doses:

  • Probiotic Blend – 4 Billion CFU
    • Lactobacillus acidophilus
    • Lactobacillus rhamnosus
    • Lactobacillus plantarum
    • Bifidobacterium lactis
    • Bifidobacterium animalis
  • Digestive Enzyme Blend – 43mg
    • Amylase
    • Bromelain
    • Lipase
  • Weight Management Blend
    • Green tea extract – 100mg
    • Slimaluma – 166mg

Let’s go through each of these blends in a little more detail to unpack what Bio X4 can and can’t do.

Probiotic Blend – 4 Billion CFU

Bio X4 contains a fairly standard mix of probiotic bacteria species. We get some Lactobacillus strains and some Bifidobacterium strains. These are two of the most abundant bacterial species in the gut, and two of the most important for regulating overall health and digestion. Introducing L. rhamnosus will be particularly beneficial to people who struggle to fully digest lactose.

By introducing a range of these bacteria species, Bio X4 will definitely help rebalance the gut in favor of a more healthful microbiome. It will also promote better digestion of lactose; something most people will benefit from.

Digestive Enzyme Blend – 43mg

The Bio X4 digestive enzyme blend contains amylase, bromelain, and lipase. Amylase is responsible for turning glycogen and starch into simple sugars. Bromelain is an exogenous enzyme found in the pineapple; it breaks down protein extremely efficiently. Lipase catalyzes the hydrolysis of fats; in other words, it helps break down fats into fatty acids.

Bromelain digestive enzyme

While these enzymes have been selected to help you digest carbohydrates, fats and protein, we don’t think they are a particularly good choice for Bio X4. Consuming digestive enzymes does not necessarily promote better digestion, and many of these enzymes will become denatured in the stomach. This is one of those things that sounds logical, but in practice it yields little fruit.

Weight Management Blend – 100mg

The Bio X4 weight management blend is just green tea extract. We suspect Nucific have called it a weight management blend to make sure you know why they’ve included green tea!

Green tea is a fantastic substance to use if you’re looking to boost your metabolism and speed up fat loss. A catechin in green tea – EGCG – has been found to directly stimulate lipolysis independently of exercise. That is, EGCG seems to encourage the use of stored fat for energy.

Bio X4 provides 100mg of high-EGCG green tea extract. While a higher dose is probably necessary to see noticeable results, 50mg of EGCG will definitely help accelerate your metabolism and promote fat loss.

Craving Control Blend – 166mg

The Bio X4 craving control blend contains one ingredient; Slimaluma. Slimaluma is a branded form of Caralluma Fimbriata. According to Nucific, this is a powerful appetite suppressant. They claim that Caralluma Fimbriata has been found to be effective at reducing hunger, and by extension, over-eating or snacking.

Caralluma Fimbriata

We have found no evidence to support this claim whatsoever. To date, we haven’t seen one robust, independent clinical trial in which people reported significantly less hunger or reduced food cravings while taking Caralluma Fimbriata. The only studies which we found showing a benefit from Caralluma Fimbriata failed to properly control for confounding factors (source). Until we see some higher quality clinical trials, we’re going to assume this ingredient is bogus.

Our thoughts on the Bio X4 formula

If you’ve read our full review of Nucific Bio X4’s ingredients above, you might think this is a good quality supplement.

But we are not particularly impressed with Bio X4, and we would certainly not recommend it to people looking to improve gut health or to people needing help with weight management.

Our first issue is with the Slimaluma. As far as we can tell, there are no good quality clinical trials proving that Caralluma fimbriata actually helps reduce food cravings. The claims made by Nucific rest on studies which did not control for things like diet and exercise.

The serving of green tea is also decidedly low for a fat loss aid. Most supplements designed to promote fat loss use green tea, but they’ll use up to 300mg of high-EGCG extract. Bio X4 gives us 50mg of EGCG, which isn’t great.

Then there’s the simple fact that digestive enzymes are ineffective when it comes to promoting better digestion. It may sound counter-intuitive, but it’s true; consuming exogenous digestive enzymes doesn’t lead to better digestion, as these enzymes are denatured (rendered useless) by your powerful stomach acid.

So really, we’re left with a very standard collection of probiotic bacteria. These are not bacteria species that you can’t get from common fermented foods like yogurt, sauerkraut, and so on.

All-in-all, Bio X4 is a severely over-priced gut health supplement. You are really paying for a standard, possibly even substandard collection of probiotic bacteria and some green tea extract. For that, the price tag is completely unjustifiable.

If you really want to overhaul your gut microbiome for optimal health and promote digestive health over the long-term, a high-quality prebiotic is a better option anyway. A good prebiotic will selectively promote the growth of healthy bacteria in your gut, which will in turn promote fat loss and better digestion anyway.

Does Bio X4 Promote Weight Loss?

Bio X4 explicitly promises to promote weight loss. A large part of Nucific Bio X4’s formula is dedicated to weight loss and weight management, which is something you can’t say about most probiotics. Most Bio X4 reviews you see online focus on the weight loss aspect of this supplement, so clearly this is one of the most important angles for consumers.

The simple truth is Nucific Bio X4 is no better at promoting weight loss than any other half-way decent probiotic or prebiotic on the market right now.

Even though it is rich in EGCG, which has been proven to accelerate weight loss, the tiny amount of green tea extract added to Bio X4 does not make it an effective weight loss supplement. Certainly not when compared to proper, professional weight loss supplements.

Nucific Bio X4 also contains a “craving control blend”. Obviously, a large part of weight loss is controlling eating; particularly problematic over-eating. Most people struggle with weight loss because they simply cannot control their diets, and caloric balance (food in vs food out) is literally the main determinant of fat loss.

Bio X4 weight loss

However, any good prebiotic or probiotic supplements act as weight loss products. Probiotics and prebiotics create a healthy gut microbiome, and having a healthy microbiome has been shown to drastically improve body composition and facilitate weight loss. These weight loss effects of probiotics and prebiotics are the result of having gut bacteria which effectively digest and process nutrients.

In other words, having a healthy digestive system will help you lose weight, and a good prebiotic or probiotic supplement will fix an unhealthy digestive system. So by extension, good prebiotics or probiotic products will help you lose weight.

We don’t think the gimmicky weight loss ingredients in Bio X4 will make much difference to your body composition.

In most cases, a high quality probiotic supplement will do more to help you lose weight than any weight loss pill. This is because most peoples’ inability to lose weight stems from their constant state of hunger, which a healthy gut microbiome helps suppress.

Quick summary: Does Bio X4 help you lose weight?

No, Bio X4 doesn’t help with weight loss any more than another good probiotic. The 100mg of green tea extract isn’t going to make a huge difference to your weight loss progress. A good probiotic will fix your gut microbiome, which will drastically improve your blood sugar control, hunger levels, and satiety. This in turn will significantly accelerate weight loss. Weight loss is complicated but most people will lose weight faster from better appetite control than gimmicky weight loss supplements.

Pricing: Is Nucific Bio X4 worth the money?

Is Nucific Bio X4 worth the money?

We don’t think so.

A single bottle will set you back an eye-watering $99.00. Yes, you read that right – $99.00 a bottle.

This is about three times as much as the leading gut health supplement on sale today, and three times as much as the most effective fat burners. So even if you wanted to both promote gut health and encourage fat loss, you’d be better off buying the top-end products in each category.

The fact that Nucific are charging $99.00 for a supplement that is essentially just some standard probiotic bacteria (which you get from fermented foods anyway), some green tea, and an untested appetite suppressant is almost offensive.

Nucific Bio X4 does offer a 90 day money back guarantee. According to a few Bio X4 reviews we’ve seen, Nucific does seem to honor the terms and conditions of their money back guarantee.

However, this does not make Bio X4 any better in terms of value for money.

The best prebiotics cost around $30 a bottle and deliver far more benefits than you’ll get from Bio X4. The proces being charged by Nucific for Bio X4 are outrageous as far as we’re concerned!

User Bio X4 Reviews: Complaints & User feedback

It’s worth looking at other Bio X4 reviews before you go ahead and spend good money on this probiotic (especially given the prices being charged by Nucific).

Obviously, an anonymous review submitted online does not have a lot of validity or worth. But when we see review after review saying the same thing, we know we’re porbably looking at a real trend.

Here is a selection of Bio X4 reviews taken from Amazon and eBay:

Bio X4 reviews and complaints

Bio X4 user reviews

Of course, we have ignored Bio X4 reviews published on the Nucific website, or any that are obviously put out by the supplement company itself.

Bio X4 Side Effects: Is it safe?

Is Bio X4 safe?

This is probably the most important question for a Bio X4 review to answer.

On the whole, we think Bio X4 is safe for the vast majority of users. That is assuming that you are using it for a limited amount of time. None of the ingredients in Bio X4 are known to regularly cause severe side effects.

Nucific Bio X4 side effects

However, while doing our Nucific Bio X4 review found the following reported side effects from various Bio X4 reviews and complaints online:

  • Upset stomach
  • Gassiness and constipation
  • Diarrhea
  • Bloating
  • Nausea
  • Joint pain
  • Acid reflux
  • Minor abdominal cramps

Please do keep in mind that these are side effects reported in user Bio X4 reviews and complaints submitted online. It is always possible that these have been submitted as malicious, negative user reviews.

There are also the general side effect concerns that come with using probiotics ofr long periods of time.

Probiotics like Bio X4 are not designed for long-term, daily use; continuing to ingest a cocktail of exogenous gut bacteria every day will eventually cause problems, including:

  1. Stomach cramps
  2. Nausea
  3. Indigestion
  4. Diarrhea
  5. Constipation

Probiotics are designed to re-balance your gut bacteria. But continuing to use them for long, unbroken periods will end up tipping the balance the other way.

Is Caralluma Fimbriata safe to use?

There is also the issue of Caralluma Fimbriata. This substance has not been thoroughly tested on humans in independent clinical trials.

The few basic clinical trials carried out on caralluma fimbriata have thus far not extended beyond 2 months. As such, we cannot say whether or not Bio X4 will cause long-term health risks.

But most users will experience no side effects while using Bio X4 for periods of 2 months or less. Any side effects that do occur are likely to be mild and transient.

This is not medical advice, and we are not doctors. You must do your own research carefully before buying any supplements. If you have any pre-existing health conditions, talk to a qualified doctor. If you have concerns about any Bio X4 ingredients, contact Nucific directly.

Bio X4 Review Conclusion: Should you buy it?

We don’t see why anybody would opt for Bio X4. At $99.00 per bottle, the price is completely unjustifiable. Instead of buying Bio X4, you could buy the single best prebiotic and the highest-quality fat burner on the market today and still save yourself about $30.

There are serious issues with the Bio X4 formula too. Slimaluma is essentially unproven; the clinical trials showing it to be an effective appetite suppressant were poorly designed and failed to control for confounding factors.

The digestive enzymes will do nothing as they will just be denatured in your stomach.

As such, Bio X4 is essentially a mix of green tea and some basic probiotics. While these ingredients will promote good gut health and fat loss, neither are suitable for long-term use, and neither will make the kind of impact promised by Nucific.

If you want to optimize your gut microbiome, promote fat loss, and enhance overall health, a good quality prebiotic is the best option.

Don’t waste your hard-earned money on over-priced, under-powered supplements like Nucific Bio X4.

See our #1 recommended supplement for total gut health:

Performance Lab Prebiotic

Performance Lab Prebiotic gut health supplement

This is easily the best supplement on the market right now for optimizing your gut health over the long term. By selectively feeding your healthy gut bacteria with specially grown inulin-FOS prebiotic fiber, Performance Lab Prebiotic helps rebelance your gut microbiome and spur the growth of healthy bacteria species every signle day.

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