Synbiotic 365 review

Synbiotic 365 Review: Does this probiotic really work?

Synbiotic 365


Short-term effects


Long-term effects







  • Does provide a diverse array of probiotic bacteria
  • Uses high quality inulin as prebiotic fiber


  • Inulin serving is pathetically small
  • Probiotics not suitable for long-term use
  • Price is high for something you can get from fermented foods and a B vitamin complex!


Synbiotic 365 is an incredibly popular probiotic supplement. However, after doing a thorough review, I have no idea why Synbiotic 365 is so widely used or how it has gained so many fans. It is a basic probiotic supplement in that it delivers a fairly standard mix of probiotic bacteria. The difference between Synbiotic 365 and every other probiotic supplement on the market is the price; $40 a box is significantly more expensive than the average basic probiotic. There’s no added ingredients and, worse still, no prebiotic fiber in this supplement. For optimal gut health, use a targeted, high quality probiotic and a high quality prebiotic.

What is Synbiotic 365?

Probiotics have become an extremely popular supplement category as of late. Food products infused with digestive enzymes and probiotic bacteria species have flooded the market, and specialist probiotic supplements are becoming much more popular. One of the most popular probiotics on sale right now is Synbiotic 365.

Like a lot of other probiotics on sale right now, Synbiotic 365 promises to completely revamp and revitalize your gut microbiome.

Synbiotic 365 review

According to the website, Synbiotic 365 delivers:

  1. Relief from digestive issues such as bloating
  2. Improved digestive health
  3. Reduced food cravings/better appetite control

These benefits would follow from having a healthier gut microbiome. Your gut microbiome has a massive impact on virtually every aspect of your health and performance, from energy levels to immune system function, so the benefits of improving gut microbiota health are extensive.

But does Synbiotic 365 really work? Does this probiotic really fix digestive problems? Is it the best supplement for all-round gut health? Is it safe? Read our detailed Synbiotic 365 review below and find out.

How Does Synbiotic 365 Work?

So how does Synbiotic 365 work exactly?

Synbiotic 365 is primarily sold as a probiotic. Probiotics are supposed to rebalance your gut microflora (bacteria) in such a way that promotes overall good health and performance.

The way probiotics do this is by introducing certain species of bacteria which are known to be beneficial for digestive health, or species which are known to out-compete harmful bacterial species in the gut.

How probiotics work

For example, most probiotics contain some Bifidobacterium bifidum. This is the most common bacteria found in the (healthy) gut of humans. As many people live lifestyles that suppress this healthful bacteria (low fiber diet, high stress working life, etc.), the typical gut has suboptimal levels of bifidobacterium bifidum. By introducing more of this bacteria species, probiotics seek to rebalance the gut and fix any related issues.

Synbiotic 365 is interesting in that it also has some prebiotic content. In our opinion, prebiotics are significantly more effective than probiotics when it comes to fixing digestive issues and promoting overall good health and performance.

Prebiotics don’t seek to keep topping up certain bacteria species, and they don’t aim to introduce foreign bacteria to out-compete harmful strains. Instead, prebiotics feed your existing, healthy gut bacteria, allowing them to thrive and dominate your gut microbiome (as they should in a healthy gut).

Prebiotics are essentially just water soluble fibers. Your healthy gut bacteria feed on water soluble fiber that passes through the stomach and into the intestine largely unaltered. The best prebiotic supplement will provide highly-bioavailable, nutritious prebiotic fiber which sleectively feed beneficial gut bacteria (leaving harmful bacteria to go hungry).

That is how Synbiotic 365 is supposed to work.

But does the formula come through and deliver on these promises?

Synbiotic 365 Ingredients

Let’s take a look at the Synbiotic 365 ingredients to see if this probiotic really delivers on its promises.

Here is a list of the Synbiotic 365 ingredients and doses as you can see on the box:

Synbiotic 365 ingredients

Here is a list of the ingredients in Synbiotic 365 in case that image doesn’t load:

  • Thiamin (B1) – 200% RDI
  • Riboflavin (B2) – 200% RDI
  • Niacin (B3) – 200% RDI
  • Vitamin B6 – 200% RDI
  • Folate – 200% RDI
  • Vitamin B12 – 1000% RDI
  • Biotin (B7) – 200% RDI
  • Pantothenic acid (B5) – 200% RDI
  • Probiotic Blend – 20 billion CFU
  • Chicory root inulin – 315mg

Our Thoughts On The Synbiotic 365 Formula

Is Synbiotic 365 a good gut health supplement? Would we recommend it to you, our readers? Let’s take a look at the benefits and the problems.


In all honesty, the Synbiotic 365 formula is pretty standard for a probiotic.

We have the usual 20 billion CFU of probiotic bacteria. The bacteria listed here are all absolutely typical for a probiotic. These are strains found naturally in the gut in varying ratios, with the likes of Bifidobacterium bifidum and Lactobacillus reuteri being the most abundant.

Introducing these strains to the gut will generally promote a healthier, more robust gut microbiome. If you have any imbalances in your gut microbiota – whether from consuming too much alcohol, not eating enough fiber, or too much stress – the species in Synbiotic 365 should be capable of rectifying that imbalance and getting your gut back in optimal condition.

It’s also encouraging to see some prebiotic fiber in Synbiotic 365; the chicory root inulin will selectively feed your healthy gut bacteria, further encouraging them to populte the gut at the expense of less helpful bacteria species.

The vitamin stack is probably unnecessary, as many people take a multivitamin or B vitmain complex daily. However, B vitamins are involved in the procesing of proteins and carbohydrates in the gut, so they are relevant ingredients for a supplement like Synbiotic 365.

But would we recommend Synbiotic 365 to you?

No, definitely not.


There are several fundamental flaws with the Synbiotic 365 formula which, in our opinion, makes it a less-than-optimal gut health supplement.

For starters, we don’t think taking a probiotic is the best way to optimize gut health. Prebiotics offer a far more effective, sustainable, and risk-free path to optimal gut health.

Probiotics inject exogenous bacteria species into your gut in unknown quantities. Often, they can cause their own problems, making imbalances worse before they get better. Using them long-term produces further complications (more in the sid effects section).

Prebiotics are much more targeted. They selectively feed your healthful gut bacteria. These healthful gut bacteria then thrive, restoring your own unique, optimal gut microflora profile in just a few weeks.

Then there’s the fact that the probiotic bacteria in Synbiotic 365 are nothing special. These are standard probiotic bacteria species that you will get from any probiotic supplement in the world. Granted, we do get a nice range here which other supplements do not. But it’s still nothing special, despite the claims made by United Naturals.

The addition of chicory root inulin doesn’t save the formula. The 315mg of inulin we get in Synbiotic 365 is nowhere near enough to properly feed your healthy gut microflora and allow them to out-compete the unhealthy bacteria in your digestive tract. The best prebiotics around at the minute provide several grams of inulin!

All things considered, this is a pretty poor formula as far as high-end gut supplements go. It doesn’t compare well to the best probiotics or the best prebiotics on sale today.

If you’re serious about optimizing your gut for health and performance, use a professional-quality prebiotic with clinically-proven ingredients.

Synbiotic 365 Side Effects

Like all probiotics, Synbiotic is unlikely to cause serious adverse health effects. Most good probiotics will provide bacteria species that are either endogenous (naturally-occuring) in the human gut, or found commonly in food.

There is nothing in Synbiotic 365 wich gives us serious cause for concern.

Synbiotic 365 side effects

That said, all probiotics can cause side effects. Consuming exogenous bacteria species in such high concentrations – and in unknown ratios – always poses risks. Common side effects from probiotics include:

  1. Bloating
  2. Nausea
  3. Gas
  4. Cramps
  5. Diarrhea
  6. Gut microbiome imbalances

The risk inherent in all probiotics, Synbiotic 365 included, is the reason we recommend prebiotics for gut health and not probiotics.

This is not medical advice and we are not doctors. You must do your own research carefully before using any probiotics or prebiotics, and talk to a qualified health professional if you have any concerns or pre-existing health conditions.

Pricing: Is Synbiotic 365 worth the money?

Is Synbiotic worth the price tag?

After doing a thorough review of the formula, we really don’t think so. To use, Synbiotic 365 looks extremely over-priced, like most probiotics of this sort.

Synbiotic 365 costs $119.00 for 3 boxes. That is $39.67 per bottle, which equals a month’s supply.

This is a lot for a supplement that provides nothing that you can’t get from a good active culture yogurt or another fermented food and a good B vitamin stack.

You’d be better off spending that money on more fermented foods, a more comprehensive probiotic supplement, or a high quality prebiotic.

Synbiotic 365 Review Conclusion: Should you buy it?

After doing a detailed review of Synbiotic 365, we are left wondering what all the fuss is about.

As far as we can tell, Synbiotic 365 is a basic probiotic – standard ingredients, some run-of-the-mill B vitamins, and a tiny serving of regular inulin.

Compared to some of the probiotics out there which come stacked with vitamins, minerals, “superfoods” and digestive enzymes, Synbiotic doesn’t look like a good option at all.

When you consider that probiotics are not even the most effective or safest way of promoting gut health, it becomes clear that Synbiotic 365 is an unattractive offer.

If you want to promote better gut microbiome health – and enjoy all the benefits that come with it – use a high-quality prebiotic.

See our #1 recommended supplement for total gut health:

Performance Lab Prebiotic

Performance Lab Prebiotic gut health supplement

This is easily the best supplement on the market right now for optimizing your gut health over the long term. By selectively feeding your healthy gut bacteria with specially grown inulin-FOS prebiotic fiber, Performance Lab Prebiotic helps rebelance your gut microbiome and spur the growth of healthy bacteria species every signle day.

Visit the website ot learn more:

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